What is HG3?

HG 3 (Hovenia Grande) is a physician developed and tested chewable dietary supplement designed to be taken with sensible consumption of alcohol resulting in prevention of hangover and improved cognition. HG 3 consists of a proprietary blend of concentrated extracts (from the fruit of Hovenia Dulcis) and Dihydromyricetin (from Ampelopsis Grossedentata). Hovenia Dulcis, commonly known as the Japanese raisin tree grows naturally in China, Japan and Korea. Its use in Chinese herbal medicine to ameliorate symptoms of acute alcohol toxicity and prevent hangovers is legendary.

Dihydromyricetin (DHM), a principally active ingredient in Hovenia and Ampelopsis has been the target of intense investigation related to its central role in blunting the effects of alcohol intoxication and prevention of hangover in an animal model.

What is an Alcohol Hangover?

“The primary alcohol related morbidity in light –to –moderate drinkers is hangover”.

Hangover is vaguely described in the medical literature as “a constellation of unpleasant physical and mental symptoms that occur after a bout of heavy alcohol intake”. Another definition used by Wiese is ‘the presence of at least two symptoms (see below for examples) occurring after the consumption and full metabolism of alcohol with sufficient severity to disrupt the performance of daily tasks and responsibilities’. Approximately “75% of individuals who drink to intoxication report experiencing a hangover at least some of the time”. The most common symptoms of hangover include headache, a general feeling of being unwell, diarrhea, nausea, loss of appetite, tremulousness, lethargy or fatigue, and difficulty concentrating. Furthermore it may be associated with increased risk for injury related to impairment of psychomotor skills (driving a car) and decreased productivity in the workplace (absenteeism and poor job performance). Lastly, individuals with hangover “have a diffuse slowing on electroencephalography (electrical brain wave study) which may persist up to 16 hours after blood alcohol levels become undetectable”.

Hangover is a word used in common everyday language to imply that one is recovering from the effects of alcohol intoxication. “I went drinking last night and now I’ve got a hangover”. However, hangover is not entirely the result of how much alcohol is consumed. For example, someone who drinks light to moderate amounts of alcohol may suffer more intense hangover symptoms if dehydration and loss of sleep were also factors. Hangover can also be worse if a person’s liver allows an alcohol breakdown product, acetaldehyde, to accumulate. For others, contributing factors may include gluten found in some beers, sulfates in wine, or byproducts of fermentation (congeners) in liquor.

On the flip side of this issue, people can unknowingly suffer intoxication due to wide variations in alcohol concentrations in different beers (4-12%), wines (6-17%), and liquors (15-75%) coupled with serving size of glass i.e. 10, 12, 16, 20, 24 or more ounces. If mixed drinks, multiple liquors of different alcohol concentrations may be used-and how full is that glass of wine? Trying to use “The standard drink” information to control alcohol consumption (National Institute of Alcohol Abuse and Alcoholism) implies that an individual knows the alcohol content in the beverages being served, takes into account the serving size, and then counts the number of standard drinks. The “standard drink” is intended as a “rule of thumb” for consumption.

Specifically, the use of HG3 to offer relief of “hangover” is not intended to embolden individuals to drink to intoxication and then use this product to avoid the uncomfortable consequences. To the contrary, HG 3 is intended to “prevent” the contribution alcohol makes to hangover in light to moderate drinkers so people can function “better” the following day.

It is important to drink responsibly.

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